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Implantable cardioverter defibrillator or ICD is a small device similar to a pacemaker, attached to the heart of a person. People suffering with conditions like arrhythmias are under the constant risk of heart failure. Irregular heartbeats caused by arrhythmias will cause sudden cardiac arrest (SCA) which will lead to stroke or death if it is not treated within a few minutes.

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Moreover, repeated 7,8 DHF treatment also significantly reduces baseline levels of BACE1 in wild type mice ( Consistent with the BACE1 reduction, C99 levels are raso r windstopper stone island significantly lowered by 7,8 DHF treatments in 5XFAD mice ( (d, e) Levels of total A (d) and A (e) were quantified by sandwich ELISAs of guanidine extracts of hemibrain samples and expressed as the percentage of vehicle treated 5XFAD levels (n mice per group). Repeated 7,8 DHF treatment almost equivalently reduced A and A levels in 5XFAD mouse brains ( vs 5XFAD, vehicle). Meanwhile, transgene derived overexpression of human full length APP was not affected by repeated administration of 7,8 DHF in 5XFAD mice (Figure 5a).

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